16,24-Cyclo-13,14-secoergost-2-ene-18,26-dioic acid, 5-chloro-14,17:14,27-diepoxy-6,13,20,22-tetrahydroxy-1,15-dioxo-, .gamma.-lactone .delta.-lactone

Names

[ Name ]:
16,24-Cyclo-13,14-secoergost-2-ene-18,26-dioic acid, 5-chloro-14,17:14,27-diepoxy-6,13,20,22-tetrahydroxy-1,15-dioxo-, .gamma.-lactone .delta.-lactone

Biological Activity

[Description]:

Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC50 value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC50 values of 5.7 and 6.8 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Stem Cell/Wnt >> Hedgehog

[References]

[1]. Arai MA, eta l. Physalin H from Solanum nigrum as an Hh signaling inhibitor blocks GLI1-DNA-complex formation. Beilstein J Org Chem. 2014 Jan 13;10:134-40.

Chemical & Physical Properties

[ Density]:
1.59g/cm3

[ Molecular Formula ]:
C₂₈H₃₁ClO₁₀

[ Molecular Weight ]:
562.99300

[ Exact Mass ]:
562.16100

[ PSA ]:
145.66000

[ LogP ]:
0.96910

[ Index of Refraction ]:
1.66

Safety Information

[ Hazard Codes ]:
Xi