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Methyl Kakuol

Names

[ CAS No. ]:
70342-29-9

[ Name ]:
Methyl Kakuol

[Synonym ]:
1-Propanone,1-(6-methoxy-1,3-benzodioxol-5-yl)
Methyl kakuol

Biological Activity

[Description]:

Methyl kakuol shows agonistic activity against TRPA1 with an EC50 of 0.27 µM[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel
Research Areas >> Neurological Disease

[Target]

TRPA1


[In Vivo]

The maximum concentration (Cmax) of Methyl kakuol at a dose of 2 g/kg (containing 1156 µg/kg, 294 µg/kg, 452 µg/kg, 852 µg/kg asarinin, sesamin, methyl kakuol, and amide A, respectively) is 98.2 ng/mL[1].

[References]

[1]. Takashi Matsumoto, et al. In Vivo Pharmacokinetic Analysis Utilizing Non-Targeted and Targeted Mass Spectrometry and In Vitro Assay against Transient Receptor Potential Channels of Maobushisaishinto and Its Constituent Asiasari Radix. Molecules. 2020 Sep 18;25(18):4283.

Chemical & Physical Properties

[ Molecular Formula ]:
C11H12O4

[ Molecular Weight ]:
208.21100

[ Exact Mass ]:
208.07400

[ PSA ]:
44.76000

[ LogP ]:
2.01660

[ Storage condition ]:
2-8°C

Related Compounds