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z-arg-amc hcl

Names

[ CAS No. ]:
70375-22-3

[ Name ]:
z-arg-amc hcl

[Synonym ]:
Z-Arg-MCA
Z-L-Arginine-4-methyl-7-coumarinylamide hydrochloride
Carbobenzoxy-L-arginine-7-amino-4-methylcoumarin hydrochloride
EINECS 274-586-3
Nalpha-Cbz-L-arginine 7-amido-4-methylcoumarin hydrochloride
Z-L-Arg 7-amido-4-methylcoumarin hydrochloride
benzyl (S)-(4-(amidinoamino)-1-{[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)amino]carbonyl}butyl)carbamate monohydrochloride
MFCD00039019

Biological Activity

[Description]:

Z-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin and papain. Z-Arg-AMC hydrochloride can be used to research activity of trypsin (Ex/Em=355/460 nm)[1][2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[References]

[1]. Paczek L, et al. Trypsin, elastase, plasmin and MMP-9 activity in the serum during the human ageing process. Age Ageing. 2008 May;37(3):318-23.

[2]. Brown A, et al. Necator americanus (human hookworm) aspartyl proteinases and digestion of skin macromolecules during skin penetration. Am J Trop Med Hyg. 1999 May;60(5):840-7.

Chemical & Physical Properties

[ Boiling Point ]:
793ºC at 760 mmHg

[ Melting Point ]:
204-205ºC

[ Molecular Formula ]:
C24H28ClN5O5

[ Molecular Weight ]:
501.96300

[ Flash Point ]:
433.4ºC

[ Exact Mass ]:
501.17800

[ PSA ]:
159.54000

[ LogP ]:
5.05500

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMF: soluble

MSDS

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Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds