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Nargenicin A1

Names

[ CAS No. ]:
70695-02-2

[ Name ]:
Nargenicin A1

Biological Activity

[Description]:

Nargenicin A1 is an antibiotic agent against various Gram-positive bacteria. Nargenicin A1 shows anti-inflammatory activity. Nargenicin A1 protects HINAE cells against Tacrolimus (HY-13756)-induced DNA damage and apoptosis. Nargenicin A1 can also be used for the research of acute myeloid leukemia[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Research Areas >> Infection
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Da Hye Kwon, et al. Nargenicin A1 attenuates lipopolysaccharide-induced inflammatory and oxidative response by blocking the NF-κB signaling pathway. EXCLI J. 2021 May 28;20:968-982.  

[2]. Dhakal D, et al. Characterization of Tailoring Steps of Nargenicin A1 Biosynthesis Reveals a Novel Analogue with Anticancer Activities. ACS Chem Biol. 2020 Jun 19;15(6):1370-1380.  

Chemical & Physical Properties

[ Density]:
1.31g/cm3

[ Boiling Point ]:
718.3ºC at 760 mmHg

[ Molecular Formula ]:
C28H37NO8

[ Molecular Weight ]:
515.60

[ Flash Point ]:
388.2ºC

[ Exact Mass ]:
515.25200

[ PSA ]:
127.31000

[ LogP ]:
2.40040

[ Index of Refraction ]:
1.595

Related Compounds