Delta (Phospho) Sleep Inducing Peptide

Delta (Phospho) Sleep Inducing Peptide (DSIP-P) is a long-lasting sleep-promoting peptide. Delta (Phospho) Sleep Inducing Peptide induces changes in the circadian locomotor behavior in rats[1][2][3].

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

Delta (Phospho) Sleep Inducing Peptide (20-300 nM) increases rat pineal N-acetyltransferase (NAT) activity induced by norepinephrine in vitro[3].

Delta (Phospho) Sleep Inducing Peptide (0.1 nmol/kg; i.v.; once daily for 4 times) induces changes in the circadian locomotor behavior[1]. Delta (Phospho) Sleep Inducing Peptide (20 or 200 pmol/kg; inject into the 3rd cerebroventricle of male rats immediately before the onset of the dark period) increases slow-wave sleep and paradoxical sleep during the subsequent dark period without shortening sleep latency at a dose of 200 pmol/kg[2]. Animal Model: Female rats from own inbred strain (KBS/K60)[1] Dosage: 0.1 nmol/kg Administration: Intravenous injection; once daily for 4 consecutive days Result: Induced rapid and mark changes in the circadian locomotor behavior when during the light (sleeping) phase testing animals became relatively more active.

[1]. Graf M, et al. Effects of repeated DSIP and DSIP-P administration on the circadian locomotor activity of rats. Pharmacol Biochem Behav. 1981 Nov;15(5):717-21.  

[2]. Nakagaki K, et al. Sleep-promoting effect following intracerebroventricular injection of a phosphorylated analogue of delta sleep-inducing peptide (DSIP-P) in rats. Neurosci Lett. 1988 Aug 31;91(2):160-4.  

[3]. Graf MV, Schoenenberger GA. Delta sleep-inducing peptide modulates the stimulation of rat pineal N-acetyltransferase activity by involving the alpha 1-adrenergic receptor. J Neurochem. 1987 Apr;48(4):1252-7.