SIRT5 inhibitor 4

Names

[ CAS No. ]:
708992-34-1

[ Name ]:
SIRT5 inhibitor 4

Biological Activity

[Description]:

SIRT5 inhibitor 4 (compound 11) is a potent, selective SIRT5 inhibitor with IC50 values of 26.4 and >400μM for SIRT5 and other SIRT subtype, respectively[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

[Target]

SIRT5:26.4 μM (IC50)

SIRT1:＞400 μM (IC50)

SIRT2:＞400 μM (IC50)

SIRT3:＞400 μM (IC50)

SIRT6:＞400 μM (IC50)

SIRT7:＞400 μM (IC50)


[In Vitro]

SIRT5 inhibitor 4 (compound 11) (6-200 µM) stabilizes SIRT5 protein with a temperature shift of 1.8℃ in a dose-dependent manner[1].

[References]

[1]. Han LY, et, al. Identification of 2-hydroxybenzoic acid derivatives as selective SIRT5 inhibitors. Eur.J.Med.Chem.2022 Jul 22, 114623

Chemical & Physical Properties

[ Molecular Formula ]:
C18H15N3O4S

[ Molecular Weight ]:
369.39

Related Compounds