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SirReal 2

Names

[ CAS No. ]:
709002-46-0

[ Name ]:
SirReal 2

[Synonym ]:
2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(1-naphthylmethyl)-1,3-thiazol-2-yl]acetamide
Acetamide, 2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]-
2-[(4,6-Dimethyl-2-pyrimidinyl)sulfanyl]-N-[5-(1-naphthylmethyl)-1,3-thiazol-2-yl]acetamide

Biological Activity

[Description]:

SirReal2 is a potent, isotype-selective Sirt2 inhibitor with an IC50 value of 140 nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

[Target]

SIRT2:140 nM (IC50)


[References]

[1]. Rumpf T, et al. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. Nat Commun. 2015 Feb 12;6:6263.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C22H20N4OS2

[ Molecular Weight ]:
420.550

[ Exact Mass ]:
420.107849

[ PSA ]:
121.31000

[ LogP ]:
5.83

[ Index of Refraction ]:
1.701

[ Storage condition ]:
-20℃

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds