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FOY 251-D4

Names

[ CAS No. ]:
71079-09-9

[ Name ]:
FOY 251-D4

[Synonym ]:
4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]-benzeneacetic Acid Monomethanesulfonate
4-(4-guanidinobenzoyloxy)phenylacetic acid
4-(4-guanidinobenzoyloxy)phenylacetic acid mesylate
4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]-benzeneacetic Acid Monomethanesulfonat
p-(p-Guanidinbenzoyloxy)-phenylessigsaeure-methansulfonat
p-(p-guanidinobenzoyloxy)phenylacetic acid methanesulphonate

Biological Activity

[Description]:

FOY 251 is an anti-proteolytic active metabolite camostate (HY-13512), acts as a proteinase inhibitor[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[Target]

proteinase[1]


[In Vitro]

FOY-251 represents a dose-dependent inhibition of equivalent current in M-1 cells[2]. FOY-251 inhibits the proteolytic activity of prostasin[2].

[References]

[1]. K Beckh, et al. Elimination of the Low-Molecular Weight Proteinase Inhibitor Camostate (FOY 305) and Its Degradation Products by the Rat Liver. Res Exp Med (Berl). 1987;187(6):401-6.

[2]. Ai Maekawa, et al. Camostat Mesilate Inhibits Prostasin Activity and Reduces Blood Pressure and Renal Injury in Salt-Sensitive Hypertension. J Hypertens . 2009 Jan;27(1):181-9.

Chemical & Physical Properties

[ Density]:
1.36g/cm3

[ Boiling Point ]:
592.6ºC at 760 mmHg

[ Melting Point ]:
194-198ºC

[ Molecular Formula ]:
C17H19N3O7S

[ Molecular Weight ]:
409.41400

[ Flash Point ]:
312.2ºC

[ Exact Mass ]:
409.09400

[ PSA ]:
188.25000

[ LogP ]:
3.29610

[ Index of Refraction ]:
1.632

Related Compounds