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1-bromo-2-(2-bromophenyl)disulfanyl-benzene

Names

[ CAS No. ]:
71112-91-9

[ Name ]:
1-bromo-2-(2-bromophenyl)disulfanyl-benzene

[Synonym ]:
1,1'-disulfanediylbis(2-bromobenzene)
di-o-bromophenyl disulfide
1,2-bis(2-bromophenyl)disulfane
bis(2-bromophenyl) disulfide
1,2-bis(2-bromophenyl) disulfide
di-(2-bromophenyl)disulfide
2-bromophenyl disulfide

Biological Activity

[Description]:

Tubulin inhibitor 28 (compound 2g) is a potent tubulin inhibitor with an IC50 value of 1.2 µM. Tubulin inhibitor 28 shows anti-proliferative activity for MCF-7 cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

IC50: 1.2 µM (tubulin)[1].


[In Vitro]

Tubulin inhibitor 28 (compound 2g) shows anti-proliferative activity with an IC50 value of >10 µM for MCF-7 cells[1].

[References]

[1]. Khodyuk RGD, et al. Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity. Bioorg Chem. 2020 Aug;101:104017.

Chemical & Physical Properties

[ Density]:
1.83g/cm3

[ Boiling Point ]:
386.9ºC at 760 mmHg

[ Molecular Formula ]:
C12H8Br2S2

[ Molecular Weight ]:
376.13000

[ Flash Point ]:
187.8ºC

[ Exact Mass ]:
373.84300

[ PSA ]:
50.60000

[ LogP ]:
6.01100

[ Index of Refraction ]:
1.745

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds