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Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da)

Names

[ CAS No. ]:
71138-97-1

[ Name ]:
Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da)

Biological Activity

[Description]:

Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is a cosolvent for preparing SDDs of low-solubility drugs. Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) exhibits no acute/subchronic/chronic toxicity in rats, with oral activity and LD50 >2.5 g/kg[1].

[Related Catalog]:

Research Areas >> Others

[In Vivo]

Hydroxypropylmethyl cellulose acetate succinate（2.5 g/kg；p.o.；单剂量）在大鼠无显著急性毒性[1]。 Hydroxypropylmethyl cellulose acetate succinate（0.63、1.25、2.5 g/kg；p.o.；每日一次，连续 2 个月，每周 6 天）在大鼠无显著亚慢性毒性[1]。 Hydroxypropylmethyl cellulose acetate succinate（1.25 g/kg、2.5 g/kg；口服；每天一次，连续 2 个月，每周 6 天）在大鼠无显著慢性毒性[1]。

[References]

[1]. Hoshi N, et al. Toxicological studies of hydroxypropylmethylcellulose acetate succinate--acute toxicity in rats and rabbits, and subchronic and chronic toxicities in rats. J Toxicol Sci. 1985 Oct;10 Suppl 2:147-85.  

Chemical & Physical Properties

[ Molecular Formula ]:
C10H22O9

[ Molecular Weight ]:
286.28

Related Compounds