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H-D-Phe-Pro-Arg-chloromethylketone trifluoroacetate salt

Names

[ CAS No. ]:
71142-71-7

[ Name ]:
H-D-Phe-Pro-Arg-chloromethylketone trifluoroacetate salt

[Synonym ]:
H-D-PHE-PRO-ARG-CHLOROMETHYLKETONE TRIFLUOROACETATE SALT
phenylalanyl-prolyl-argininemethylchloride
H-D-PHE-PRO-ARG-CMK TFA

Biological Activity

[Description]:

PPACK is a plasminogen activator (rt-PA) inhibitor. PPACK can inhibit changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin. PPACK also inhibits the binding of rt-PA to plasma protease inhibitors[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> PAI-1
Research Areas >> Cardiovascular Disease

[References]

[1]. Mohler MA, et, al. D-Phe-Pro-Arg-chloromethylketone: its potential use in inhibiting the formation of in vitro artifacts in blood collected during tissue-type plasminogen activator thrombolytic therapy. Thromb Haemost. 1986 Oct 21;56(2):160-4.  

Chemical & Physical Properties

[ Molecular Formula ]:
C21H31ClN6O3

[ Molecular Weight ]:
450.96

[ Exact Mass ]:
466.21000

[ PSA ]:
163.63000

[ LogP ]:
2.25500

[ Storage condition ]:
-15°C

Related Compounds