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Z-Phe-Ala-diazomethylketone

Names

[ CAS No. ]:
71732-53-1

[ Name ]:
Z-Phe-Ala-diazomethylketone

[Synonym ]:
Z-Phe-Ala-DMK
Carbamic acid,((1S)-2-(((1S)-3-diazo-1-methyl-2-oxopropyl)amino)-2-oxo-1-(phenylmethyl)ethyl)-,phenylmethyl ester,(S-(R*,R*))
Carbobenzoxycarbonyl-L-phenylalanyl-L-alanine-D-diazomethane
Z-Phe-Ala-Diazomethylketone
Benzyloxycarbonylphenylalanylalanine diazomethyl ketone
Z-F--DMK
Z-Phe-ala-diazomethane
Carbamic acid,(2-((3-diazo-1-methyl-2-oxopropyl)amino)-2-oxo-1-(phenylmethyl)ethyl)-,phenylmethyl ester,(S-(R*,R*))

Biological Activity

[Description]:

Z-Phe-Ala-diazomethylketone binds directly to Aβ42 monomers and small oligomers. Z-Phe-Ala-diazomethylketone inhibits the formation of Aβ42 dodecamers and inhibits Aβ42 fibril formation in the solution. Z-Phe-Ala-diazomethylketone has the potential for neurodegenerative disorders research[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

Chemical & Physical Properties

[ Molecular Formula ]:
C21H22N4O4

[ Molecular Weight ]:
394.42400

[ Exact Mass ]:
394.16400

[ PSA ]:
125.62000

[ LogP ]:
4.19848

[ Storage condition ]:
-15°C

Related Compounds