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GADOTERIC ACID

Names

[ CAS No. ]:
72573-82-1

[ Name ]:
GADOTERIC ACID

[Synonym ]:
Gadolinium 2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetic acid
Gadoteric
gadolinium(III) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid

Biological Activity

[Description]:

Gadoteric acid is a macrocyclic, paramagnetic, gadolinium-based contrast agent that can be used for magnetic resonance imaging (MRI) of the brain, spine, and related tissues. In particular, Gadoteric acid is able to detect and visualize areas of blood-brain barrier disruption and abnormal vascular distribution[1][2].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[In Vitro]

在肝细胞癌（尤其是高血管病变）的 DCE-MRI 中，Gadoteric acid 提供了更好的，更明显的对比度，以及早期增强的可感知性和更强的冲洗性[1]。

[References]

[1]. Federico Collettini, et al. MR imaging of hepatocellular carcinoma: prospective intraindividual head-to-head comparison of the contrast agents gadoxetic acid and gadoteric acid. Sci Rep. 2022 Nov 3;12(1):18583.  

[2]. Martin Maurer, et al. Tolerability and diagnostic value of gadoteric acid in the general population and in patients with risk factors: results in more than 84,000 patients. Eur J Radiol. 2012 May;81(5):885-90.  

Chemical & Physical Properties

[ Boiling Point ]:
701.6ºC at 760 mmHg

[ Molecular Formula ]:
C16H25GdN4O8

[ Molecular Weight ]:
558.64200

[ Flash Point ]:
378.1ºC

[ Exact Mass ]:
559.09100

[ PSA ]:
160.93000

[ Storage condition ]:
2-8°C

Related Compounds