Propanamide,2-amino-N-[(3S,4R,4aR,5R,6R)-3-(dichloromethyl)-3,4,4a,5,6,7-hexahydro-5,6,8-trihydroxy-3-methyl-1-oxo-1H-2-benzopyran-4-yl]-,(2S)-
Names
[ CAS No. ]:
72615-20-4
[ Name ]:
Propanamide,2-amino-N-[(3S,4R,4aR,5R,6R)-3-(dichloromethyl)-3,4,4a,5,6,7-hexahydro-5,6,8-trihydroxy-3-methyl-1-oxo-1H-2-benzopyran-4-yl]-,(2S)-
[Synonym ]:
bactobolin A
BN 183B
Bactobolin
Antibiotic BN 183B
Chemical & Physical Properties
[ Density]:
1.55g/cm3
[ Boiling Point ]:
642.9ºC at 760 mmHg
[ Molecular Formula ]:
C14H20Cl2N2O6
[ Molecular Weight ]:
383.22400
[ Flash Point ]:
342.6ºC
[ Exact Mass ]:
382.07000
[ PSA ]:
142.11000
[ LogP ]:
0.58260
[ Index of Refraction ]:
1.613
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CP1315000
- CHEMICAL NAME :
- Bactobolin
- CAS REGISTRY NUMBER :
- 72615-20-4
- LAST UPDATED :
- 199309
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C14-H20-Cl2-N2-O6
- MOLECULAR WEIGHT :
- 383.26
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6250 ug/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 33,1054,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 3,177,1980