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Tianeptine

Names

[ CAS No. ]:
72797-41-2

[ Name ]:
Tianeptine

[Synonym ]:
Tianeptine

Biological Activity

[Description]:

Tianeptine is a selective facilitator of 5-HT uptake in vitro and in vivo. IC50 Value: N/ATarget: 5-HT ReceptorTianeptine has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50 > 10 μM) and has no effect on noradrenalin or dopamine uptake. Antidepressant, analgesic and neuroprotective following systemic administration in vivo.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Research Areas >> Neurological Disease

[References]

[1]. Broqua P; Baudrie V; Chaouloff F Differential effects of the novel antidepressant tianeptine on L-5-hydroxytryptophan (5-HTP)-elicited corticosterone release and body weight loss. Eur Neuropsychopharmacol. 1992 Jun;2(2):115-20.


[Related Small Molecules]

Harmine | Pimavanserin | Serotonin hydrochloride | Sodium Ferulate | Thioridazine hydrochloride | Brexpiprazole | Risperidone | TG6-10-1 | Cariprazine | Quetiapine | SERTINDOLE | Alprenolol hydrochloride | B-HT 920 | Ketanserin | Palonosetron hydrochloride

Chemical & Physical Properties

[ Density]:
1.38±0.1 g/cm3(Predicted)

[ Boiling Point ]:
609.2±65.0 °C(Predicted)

[ Melting Point ]:
129-131℃

[ Molecular Formula ]:
C21H25ClN2O4S

[ Molecular Weight ]:
436.95200

[ Exact Mass ]:
436.12200

[ PSA ]:
95.09000

[ LogP ]:
5.72930

[ Storage condition ]:
-20℃

Related Compounds