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Linderalactone

Names

[ CAS No. ]:
728-61-0

[ Name ]:
Linderalactone

[Synonym ]:
(1R)-3,8-Dimethyl-5,14-dioxatricyclo[10.2.1.0]pentadeca-2(6),3,8,12(15)-tetraen-13-one
6H-4,7-Methenofuro[3,2-c]oxacycloundecin-6-one, 4,8,9,12-tetrahydro-3,11-dimethyl-, (4R)-
(R,10E)-4,8,9,12-Tetrahydro-3,11-dimethyl-6H-4,7-methenofuro[3,2-c]oxacycloundecin-6-one
6H-4,7-Methenofuro(3,2-c)oxacycloundecin-6-one, 4,8,9,12-tetrahydro-3,11-dimethyl-, (4R,10E)-
Linderalactone

Biological Activity

[Description]:

Linderalactone is an important sesquiterpene lactone isolated from Radix linderae. Linderalactone inhibits cancer growth by modulating the expression of apoptosis-related proteins and inhibition of JAK/STAT signalling pathway. Linderalactone also inhibits the proliferation of the lung cancer A-549 cells with an IC50 of 15 µM[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[In Vitro]

Linderalactone (0-100 μM; 24 hours; A549 cells) treatment inhibits the growth of A549 cells concentration-dependently. The IC50 of linderalactone is 15 µM[1]. Linderalactone (7.5-30 μM; A549 cells) treatment induces apoptosis in A549 cells in a dose-dependent manner[1]. Linderalactone (7.5-30 μM; 24 hours; A549 cells) treatment induces G2/M cell cycle arrest of A549 cells dose-dependently[1]. Linderalactone (7.5-30 μM; A549 cells) inhibits the expression of STAT1, JAK1 and JAK2. Linderalactone could also inhibit the phosphorylation of pSTAT1, pSTAT-2, pJAK1 and pJAk2[1]. Cell Viability Assay[1] Cell Line: Lung cancer A549 cells Concentration: 0 μM, 1.6 μM, 3.2 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM Incubation Time: 24 hours Result: Inhibited the growth of A549 cells concentration-dependently. Apoptosis Analysis[1] Cell Line: Lung cancer A549 cells Concentration: 7.5 μM, 15 μM, 30 μM Incubation Time: Result: Induced apoptosis in A549 cells in a dose-dependent manner. Cell Cycle Analysis[1] Cell Line: Lung cancer A549 cells Concentration: 7.5 μM, 15 μM, 30 μM Incubation Time: 24 hours Result: Induced G2/M cell cycle arrest. Western Blot Analysis[1] Cell Line: Lung cancer A549 cells Concentration: 7.5 μM, 15 μM, 30 μM Incubation Time: Result: Inhibited the JAK/STAT pathway in A549 cells.

[References]

[1]. Deng Y, et al. Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins, G2/M cell cycle arrest and inhibition of JAK/STAT signalling pathway. J BUON. 2019 Mar-Apr;24(2):566-571.

[2]. Qinghua Sun, et al. Preparative Isolation and Purification of Linderalactone and Lindenenol from Radix linderae by HSCCC. Journal of Liquid Chromatography & Related Technologies. Aug 2005:113-121.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
437.9±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H16O3

[ Molecular Weight ]:
244.286

[ Flash Point ]:
218.6±28.7 °C

[ Exact Mass ]:
244.109940

[ PSA ]:
39.44000

[ LogP ]:
3.27

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.572

[ Storage condition ]:
2-8C

Related Compounds