Somatostatin-28 trifluoroacetate salt

Names

[ Name ]:
Somatostatin-28 trifluoroacetate salt

[Synonym ]:
Somatostatin-28
Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys
Somatostatin 28,Cyclic
MFCD00076772
Somatostatin-28 (sheep) 28

Biological Activity

[Description]:

Somatostatin-28 (sheep) is a biologically active polypeptide, synthesised in the proximal intestinal epithelial cells. Somatostatin-28 (sheep) suppresses glucose-stimulated insulin secretion without affecting circulating basal insulin concentration. Somatostatin-28 (sheep) also targets to somatostatin receptor subtype 5 (SSTR5) to regulate GLP-1 secretion[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor

Research Areas >> Metabolic Disease

[Target]

SSTR5

[In Vitro]

Somatostatin-28 剂量依赖地抑制胃泌素释放肽刺激的 GLP-1 分泌，EC50 为 0.01 nM[1]。

[In Vivo]

Somatostatin-28 (sheep) (1.1 pmol/kg/min; 通过颈静脉导管静脉注射; 15 min) 抑制 25 μg/kg/min 葡萄糖诱导绵羊胰岛素分泌[2]。 Animal Model: Finn-Dorset Horn cross bred sheep (2-5 years old, 70-75 kg)[2] Dosage: 1.1 pmol/kg/min for 15 min, with or without 25 μg/kg/min glucose; Administration: Intravenous injection via a jugular catheter; Result: Significantly inhibited insulin secretion, resulted serum concentrations decreasing from about 200 to 150 pmol/L.

[References]

[1]. Martin PA, et al. Effects of somatostatin-28 on circulating concentrations of insulin and gut hormones in sheep. J Endocrinol. 1996 Oct;151(1):107-12.

[2]. Chisholm C, et al. Somatostatin-28 regulates GLP-1 secretion via somatostatin receptor subtype 5 in rat intestinal cultures. Am J Physiol Endocrinol Metab. 2002 Aug;283(2):E311-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃₇H₂₀₇N₄₁O₃₉S₃

[ Molecular Weight ]:
3148.56000

[ Exact Mass ]:
3146.46000

[ PSA ]:
1392.71000

[ LogP ]:
0.20370

[ Storage condition ]:
-20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Somatostatin and its receptor family.

Front. Neuroendocrinol. 20 , 157-198, (1999)

Somatostatin (SST), a regulatory peptide, is produced by neuroendocrine, inflammatory, and immune cells in response to ions, nutrients, neuropeptides, neurotransmitters, thyroid and steroid hormones, ...

Somatostatin receptor subtype-5 mediates inhibition of peptide YY secretion from rat intestinal cultures.

Am. J. Physiol. 279 , G983-G989, (2000)

Somatostatin-14 (S-14) and somatostatin-28 (S-28) bind to five distinct membrane receptors (SSTRs), but S-28 has higher affinity for SSTR-5. Whether S-28 acting through SSTR-5 regulates inhibition of ...

Intracisternal injection of somatostatin receptor 5-preferring agonists induces a vagal cholinergic stimulation of gastric emptying in rats.

J. Pharmacol. Exp. Ther. 293 , 1099-1105, (2000)

We previously showed that the somatostatin receptor 5 (sst(5))-preferring agonist BIM-23052 injected intracisternally (i.c. ; 0.8 nmol/rat) stimulated gastric emptying of a non-nutrient meal in consci...