(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin trifluoroacetate salt

Names

[ CAS No. ]:
73168-24-8

[ Name ]:
(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin trifluoroacetate salt

[Synonym ]:
Avpa
Aavp
MANNING COMPOUND
AVPX

Biological Activity

[Description]:

(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin (SKF 100273) is a vasopressin V1 receptor selective antagonist[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor

Research Areas >> Metabolic Disease

[References]

[1]. Arai Y, et al. New topics in vasopressin receptors and approach to novel drugs: research and development of conivaptan hydrochloride (YM087), a drug for the treatment of hyponatremia. J Pharmacol Sci. 2009 Jan;109(1):53-9.

Chemical & Physical Properties

[ Density]:
1.5 g/cm3

[ Molecular Formula ]:
C₅₂H₇₄N₁₄O₁₂S₂

[ Molecular Weight ]:
1151.36

[ Exact Mass ]:
1150.51000

[ PSA ]:
475.01000

[ LogP ]:
3.52940

[ Index of Refraction ]:
1.695

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H332

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20

[ Safety Phrases ]:
36

[ RIDADR ]:
NONH for all modes of transport

Articles

Peripheral mechanisms involved in the pressor and bradycardic effects of centrally administered arachidonic acid

Prostaglandins Leukot. Essent. Fatty Acids 78(6) , 361-8, (2008)

In the current study, we aimed to determine the cardiovascular effects of arachidonic acid and peripheral mechanisms mediated these effects in normotensive conscious rats. Studies were performed in ma...

Contractile responses of human thyroid arteries to vasopressin.

Life Sci. 93(15) , 525-9, (2013)

In the present study we investigated the intervention of nitric oxide and prostacyclin in the responses to vasopressin of isolated thyroid arteries obtained from multi-organ donors.Paired artery rings...

Selective blockade of oxytocin and vasopressin V(1a) receptors in anaesthetised rats: evidence that activation of oxytocin receptors rather than V(1a) receptors increases sodium excretion.

Nephron. Exp. Nephrol. 117(3) , p21-6, (2011)

Although it is known that moderate-to-high doses of the neurohypophysial hormones oxytocin and vasopressin are natriuretic, doubts remain over the identity of the receptors responsible. To address thi...