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DL-PDMP

Names

[ CAS No. ]:
73257-80-4

[ Name ]:
DL-PDMP

[Synonym ]:
(±)-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride
Decanamide, N-(2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl)-, hydrochloride
(+/-)-threo-pdmp hydrochloride
rv 538
(+/-)-pdmp hydrochloride
(+/-)-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride
Decanamide, N-[2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, hydrochloride (1:1)
d,l-threo-pdmp hcl
N-[1-Hydroxy-3-(4-morpholinyl)-1-phenyl-2-propanyl]decanamide hydrochloride (1:1)
dl-pdmp
1-phenyl-2-decanoylamino-3-morpholino-1-propanol,hcl
dl-threo-pdmp,hydrochloride
N-(2-Hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl)decanamide hydrochloride
(+/-)-pdmp hcl
PDMP hydrochloride

Biological Activity

[Description]:

PDMP hydrochloride is a glucosylceramide synthase (GCS) inhibitor. PDMP hydrochloride induces apoptosis in K562/A02 cells. PDMP hydrochloride can be used in cancer (such as leukemia) research[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[References]

[1]. Casson L, et al. Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins. PLoS One. 2013;8(1):e54525.  

[2]. Yin L, et al. Effect of PDMP, a glucosylceramide synthase inhibitor, on reversion of daunorubicin resistance in human leukemia cell line K562/A02. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Feb;18(1):79-84.  

Chemical & Physical Properties

[ Boiling Point ]:
555.1ºC at 760 mmHg

[ Molecular Formula ]:
C23H39ClN2O3

[ Molecular Weight ]:
427.020

[ Flash Point ]:
289.5ºC

[ Exact Mass ]:
426.264923

[ PSA ]:
61.80000

[ LogP ]:
4.80850

Safety Information

[ WGK Germany ]:
3

Related Compounds