Geldanamycin,18,21-didehydro-6,17-didemethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxy-6-methyl-11-O-methyl-,(6S,15R)-
Names
[ CAS No. ]:
73341-73-8
[ Name ]:
Geldanamycin,18,21-didehydro-6,17-didemethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxy-6-methyl-11-O-methyl-,(6S,15R)-
[Synonym ]:
macbecin II
Chemical & Physical Properties
[ Density]:
1.19g/cm3
[ Boiling Point ]:
698.9ºC at 760 mmHg
[ Molecular Formula ]:
C30H44N2O8
[ Molecular Weight ]:
560.67900
[ Flash Point ]:
376.5ºC
[ Exact Mass ]:
560.31000
[ PSA ]:
149.57000
[ LogP ]:
5.81680
[ Index of Refraction ]:
1.565
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OL9056000
- CHEMICAL NAME :
- Macbecin II
- CAS REGISTRY NUMBER :
- 73341-73-8
- LAST UPDATED :
- 198509
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C30-H44-N2-O8.H2-O
- MOLECULAR WEIGHT :
- 578.78
- WISWESSER LINE NOTATION :
- T6-19- A GMV IU KU OU&TJ AQ DQ I1 M1 NOVZ O1 Q1 RO1 SO1 U1 VO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - mouse Leukocyte
- DOSE/DURATION :
- 10 umol/L
- REFERENCE :
- PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 24,321,1983