<Suppliers Price>

CID 9998128

Names

[ CAS No. ]:
733807-13-1

[ Name ]:
CID 9998128

[Synonym ]:
4-Quinazolinamine, N-1H-indazol-5-yl-2-(6-methyl-2-pyridinyl)-
N-(1H-Indazol-5-yl)-2-(6-methyl-2-pyridinyl)-4-quinazolinamine
N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine

Biological Activity

[Description]:

CID 9998128 is a potential multi-target drug for the Alzheimer's disease (AD), inhibits the Aβ42 amyloid fibrillization and is capable to clear Aβ42 fibrils; strongly binds to both amyloid beta 42 (Aβ42) fibrils and β-secretase and the van der Waals interaction is dominating over the electrostatic interaction in binding affinity.

[References]

References 1. Thai NQ, et al. ACS Chem Neurosci. 2018 May 18. doi: 10.1021/acschemneuro.8b00091. View Related Products by Target Amyloids

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
536.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H16N6

[ Molecular Weight ]:
352.392

[ Flash Point ]:
278.5±30.1 °C

[ Exact Mass ]:
352.143646

[ LogP ]:
3.06

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.779

Related Compounds