(-)-LEUKOTRIENE A4 METHYL ESTER

Names

[ Name ]:
(-)-LEUKOTRIENE A4 METHYL ESTER

[Synonym ]:
LTA4-methyl ester
leukotriene A methyl ester
2-Oxiranebutanoic acid, 3-[(1E,3E,5Z,8Z)-1,3,5,8-tetradecatetraenyl]-, methyl ester, (2S,3S)-
(-)-Leukotriene A4 methyl ester
2-Oxiranebutanoic acid, 3-[(1E,3E,5Z,8Z)-1,3,5,8-tetradecatetraen-1-yl]-, methyl ester, (2S,3S)-
Methyl 4-{(2S,3S)-3-[(1E,3E,5Z,8Z)-1,3,5,8-tetradecatetraen-1-yl]-2-oxiranyl}butanoate
2-Oxiranebutanoic acid,3-[(1E,3E,5Z,8Z)-1,3,5,8-tetradecatetraenyl]-,methyl ester,(2S,3S)
5S,6S-6-epi-Leukotriene A4 methyl ester
5S,6S-Leukotriene A4 methyl ester

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
442.5±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₃₂O₃

[ Molecular Weight ]:
332.477

[ Flash Point ]:
167.7±8.1 °C

[ Exact Mass ]:
332.235138

[ PSA ]:
38.83000

[ LogP ]:
5.51

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.529

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
F,Xn,N

[ Risk Phrases ]:
11-36/37/38-48/20-51/53-62-65-67

[ Safety Phrases ]:
9-16-29-33-36/37-61-62

[ RIDADR ]:
UN 1208 3/PG 2

Precursor & DownStream

Precursor

DownStream

Articles

Transcellular metabolism of neutrophil-derived leukotriene A4 by human platelets. A potential cellular source of leukotriene C4.

J. Biol. Chem. 263 , 174, (1988)

Transformation of leukotriene (LT) A4 into leukotriene C4 has been found to be carried out by human platelets in a rather efficient manner. LTC4 was characterized by a combination of high performance ...

Transformation of leukotriene A4 methyl ester to leukotriene C4 monomethyl ester by cytosolic rat glutathione transferases.

FEBS Lett. 175(2) , 289-93, (1984)

Six major basic cytosolic glutathione transferases from rat liver catalyzed the conversion of leukotriene A4 methyl ester to the corresponding leukotriene C4 monomethyl ester. Glutathione transferase ...

Leukotriene C synthase in mouse mastocytoma cells. An enzyme distinct from cytosolic and microsomal glutathione transferases.

Biochem. J. 250(3) , 713-8, (1988)

Leukotriene C4 synthesis was studied in preparations from mouse mastocytoma cells. Enzymic conjugation of leukotriene A4 with glutathione was catalysed by both the cytosol and the microsomal fraction....