Hamaudol
Names
Biological Activity
[Description]:
Hamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol shows significant inhibitory activity on cyclooxygenase (COX)-1 and COX-2 activities with IC50 values of 0.30, 0.57 mM, respectively, and has potent analgesia and anti-inflammary effects[1][2].
[Related Catalog]:
[Target]
COX-1:0.3 mM (IC50)
COX-2:0.57 mM (IC50)
[In Vivo]
Hamaudol (Compound 7) increases the potency to exhibit a potent analgesia at doses of 1, 5 and 10 mg/kg in mice, although it do not show clear dose dependency[1].
[References]
Chemical & Physical Properties
[ Boiling Point ]:
464.7±45.0 °C at 760 mmHg
[ Melting Point ]:
197.0-197.5 °C
[ Molecular Formula ]:
C15H16O5
[ Molecular Weight ]:
276.28500
[ Exact Mass ]:
276.10000
[ PSA ]:
79.90000
[ LogP ]:
1.88140
[ Storage condition ]:
2-8°C