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Hamaudol

Names

[ CAS No. ]:
735-46-6

[ Name ]:
Hamaudol

[Synonym ]:
Hamaudol

Biological Activity

[Description]:

Hamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol shows significant inhibitory activity on cyclooxygenase (COX)-1 and COX-2 activities with IC50 values of 0.30, 0.57 mM, respectively, and has potent analgesia and anti-inflammary effects[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-1:0.3 mM (IC50)

COX-2:0.57 mM (IC50)


[In Vivo]

Hamaudol (Compound 7) increases the potency to exhibit a potent analgesia at doses of 1, 5 and 10 mg/kg in mice, although it do not show clear dose dependency[1].

[References]

[1]. Okuyama E, et al. Analgesic components of saposhnikovia root (Saposhnikovia divaricata). Chem Pharm Bull (Tokyo). 2001 Feb;49(2):154-60.

[2]. Mingshan Zheng, et al. The Constituents Isolated from Peucedanum japonicum Thunb. and their Cyclooxygenase (COX) Inhibitory Activity. Korean Journal of Medicinal Crop Science, 2005, 13(2).

Chemical & Physical Properties

[ Boiling Point ]:
464.7±45.0 °C at 760 mmHg

[ Melting Point ]:
197.0-197.5 °C

[ Molecular Formula ]:
C15H16O5

[ Molecular Weight ]:
276.28500

[ Exact Mass ]:
276.10000

[ PSA ]:
79.90000

[ LogP ]:
1.88140

[ Storage condition ]:
2-8°C


Related Compounds