alpha-methyl-dl-tyrosine methyl ester hydrochloride

Names

[ Name ]:
alpha-methyl-dl-tyrosine methyl ester hydrochloride

[Synonym ]:
MFCD00012606
EINECS 230-900-0
AMPT
2-Methyl-4-hydroxy-DL-phenylalanine methyl ester hydrochloride

Biological Activity

[Description]:

α-Methyltyrosine methyl ester hydrochloride is a competitive tyrosine hydroxylase inhibitor that inhibits the conversion of tyrosine to dopamine. α-Methyltyrosine methyl ester hydrochloride can be used as a tool for sympathetic nervous system research[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. G Magnusson, et al. Renal lesions induced by alpha-methyltyrosine methylester and alpha-methyltyrosine. Acta Pharmacol Toxicol (Copenh). 1970;28(6):435-44.

Chemical & Physical Properties

[ Boiling Point ]:
336.4ºC at 760 mmHg

[ Melting Point ]:
192 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₁H₁₆ClNO₃

[ Molecular Weight ]:
245.70300

[ Flash Point ]:
157.2ºC

[ Exact Mass ]:
245.08200

[ PSA ]:
72.55000

[ LogP ]:
2.32740

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: 50 mg/mL, clear, faintly yellow

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YP2900000

CHEMICAL NAME :: p-Tyrosine, alpha-methyl-, methyl ester, hydrochloride, (+-)-

CAS REGISTRY NUMBER :: 7361-31-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C11-H15-N-O3.Cl-H

MOLECULAR WEIGHT :: 245.73

WISWESSER LINE NOTATION :: QR D1XZ1&VO1 &GH, -R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 28,227,1974

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
YP2900000

[ HS Code ]:
2922509090

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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