Quinpirole dihydrochloride

Names

[ Name ]:
Quinpirole dihydrochloride

[Synonym ]:
(+/-)-quinpirole dihydrochloride

Biological Activity

[Description]:

rel-Quinpirole (rel-LY 141865) dihydrochloride, an ergot compound, is a selective dopamine (DA) D2 receptor agonist. rel-Quinpirole dihydrochloride can be used for research on neurological diseases[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[References]

[1]. X T Hu, et al. Disinhibition of nucleus accumbens neurons by the dopamine D2 receptor agonist LY-141865: prevented by 6-OHDA pretreatment. Brain Res. 1988 Mar 22;444(2):389-93.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₂₂ClN₃

[ Molecular Weight ]:
255.78700

[ Exact Mass ]:
255.15000

[ PSA ]:
31.92000

[ LogP ]:
2.73880

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae.

J. Neurosci. 31 , 5512-25, (2011)

An imbalance in dopamine-mediated neurotransmission is a hallmark physiological feature of neuropsychiatric disorders, such as schizophrenia. Recent evidence demonstrates that dopamine D(2) receptors,...

A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease.

Hum. Mol. Genet. 24(7) , 1929-44, (2015)

The essential micronutrient manganese is enriched in brain, especially in the basal ganglia. We sought to identify neuronal signaling pathways responsive to neurologically relevant manganese levels, a...

Biphasic effect of D-2 agonist quinpirole on locomotion and movements.

Eur. J. Pharmacol. 161 , 151-157, (1989)

The effects of the D-2 agonist quinpirole on forward progression, and on vertical and lateral movements, were measured for 2 h in rats injected with either saline, 0.03, 0.125, 0.5 or 8 mg/kg of the d...