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TRH-βNA

Names

[ CAS No. ]:
73644-58-3

[ Name ]:
TRH-βNA

[Synonym ]:
TRH-BETANA
TRH-bNA
Pyr-His-Pro-bNA
THYROTROPIN-RELEASING HORMONE-BETANA
PYR-HIS-PRO-BETANA
pyroglutamyl-histidyl-prolyl-2-naphthylamide

Biological Activity

[Description]:

TRH-βNA is a substrate for determining the membrane TRH-deamidating enzyme (TRH-DE) activity and membrane pyroglutamyl aminopeptidase II (PPII) activity[1][2].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Müller-Fielitz H, et al. Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis. Nat Commun. 2017 Sep 7;8(1):484.  

[2]. Alvarez-Salas E, et al. Food-restricted and dehydrated-induced anorexic rats present differential TRH expression in anterior and caudal PVN. Role of type 2 deiodinase and pyroglutamyl aminopeptidase II. Endocrinology. 2012 Aug;153(8):4067-76.  

Chemical & Physical Properties

[ Density]:
1.47 g/cm3

[ Molecular Formula ]:
C26H28N6O4

[ Molecular Weight ]:
488.53800

[ Exact Mass ]:
488.21700

[ PSA ]:
136.29000

[ LogP ]:
2.22910

[ Index of Refraction ]:
1.729

Related Compounds