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PNU-282987 S enantiomer free base

Names

[ CAS No. ]:
737727-12-7

[ Name ]:
PNU-282987 S enantiomer free base

[Synonym ]:
Benzamide, N-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-4-chloro-
N-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide
PNU-282987 (S enantiomer free base)

Biological Activity

[Description]:

PNU-282987 S enantiomer free base is the S-enantiomer of PNU-282987 free base. PNU-282987 is an α7 nicotinic acetylcholine receptor (α7 nAChR) agonist.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR
Signaling Pathways >> Neuronal Signaling >> nAChR
Research Areas >> Others

[References]

[1]. Bodnar AL, et al. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem. 2005 Feb 24;48(4):905-8.


[Related Small Molecules]

PNU 282987 | Carbachol | GTS-21 | Methyllycaconitine citrate | Monepantel | Hexamethonium bromide | PNU-120596 | Centrophenoxine hydrochloride | ZSET1446 | Aniracetam | Desformylflustrabromine hydrochloride | EVP-6124 (hydrochloride) | α-Lobeline Hydrochcloride | ABT 594 hydrochloride | Varenicline

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
431.5±30.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H17ClN2O

[ Molecular Weight ]:
264.751

[ Flash Point ]:
214.8±24.6 °C

[ Exact Mass ]:
264.102936

[ LogP ]:
2.49

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.612

[ Storage condition ]:
2-8℃

Related Compounds