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nifenalol

Names

[ CAS No. ]:
7413-36-7

[ Name ]:
nifenalol

[Synonym ]:
Methanesulfonamide,N-[4-[(1R)-2-chloro-1-hydroxyethyl]phenyl]
(R)-2-isopropylamino-1-(4-nitro-phenyl)-ethanol
2-chloro-1-(4'-methanesulfonamidophenyl)ethanol
N-{4-[(1R)-2-chloro-1-hydroxyethyl]phenyl}methanesulfonamide
(R)-(-)-N-[4-(1-hydroxy-2-chloroethyl)phenyl]methanesulfonamide
(R)-nifenalol

Biological Activity

[Description]:

Nifenalol is a β-adrenergic receptor blocker. Nifenalol inhibits β-adrenoceptor differentiation in right atrium, diaphragm and adipose tissue in a rat model[1][2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

Beta-1 adrenergic receptor


[References]

[1]. Harms HH, et al. Differentiation of beta-adrenoceptors in right atrium, diaphragm and adipose tissue of the rat, using stereoisomers of propranolol, alprenolol, nifenalol and practolol. Life Sci. 1977 Jul 1;21(1):123-8.  

Chemical & Physical Properties

[ Density]:
1.173g/cm3

[ Boiling Point ]:
377.4ºC at 760 mmHg

[ Molecular Formula ]:
C11H16N2O3

[ Molecular Weight ]:
224.26

[ Flash Point ]:
182ºC

[ Exact Mass ]:
224.11600

[ PSA ]:
78.08000

[ LogP ]:
2.54030

[ Index of Refraction ]:
1.555

Related Compounds