CAS#:7414-56-4 | ADENYLYLMETHYLENEDIPHOSPHONATE SODIUM SALT

[Description]:

AMP-PCP disodium is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP disodium binding favors the formation of the active homodimer of Hsp90[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> HSP

Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

[Target]

HSP90:3.8 μM (Kd)

[In Vitro]

AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP[1].

[References]

[1]. Zhang H, et al. A dynamic view of ATP-coupled functioning cycle of Hsp90 N-terminal domain. Sci Rep. 2015 Apr 13;5:9542.

[ Molecular Formula ]:
C₁₁H₁₆N₅Na₂O₁₂P₃

[ Molecular Weight ]:
549.17

[ Storage condition ]:
-20°C

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H311-H315-H319-H331-H335

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T

[ Risk Phrases ]:
23/24/25-36/37/38

[ Safety Phrases ]:
22-26-36-45

[ RIDADR ]:
NONH for all modes of transport

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ADENYLYLMETHYLENEDIPHOSPHONATE SODIUM SALT

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