Guanosine-5'-diphosphate disodium salt

Names

[ Name ]:
Guanosine-5'-diphosphate disodium salt

[Synonym ]:
5'-GDP-Na
MFCD00084665
GDP.Na2
Guanosine, 5'-(trihydrogen diphosphate), sodium salt (1:2)
5'-GDP,2Na
Disodium 5'-O-{[(hydroxyphosphinato)oxy]phosphinato}guanosine
Einecs 231-026-2
GDP,NA2H
5'-GDP-Na2
5'-GDP 3NA
GUANOSINE-5'-DIPHOSPHORIC ACID,DISODIUM
Guanosine-5'-diphosphatedisodiumsalt

Biological Activity

[Description]:

Guanosine 5'-diphosphate disodium salt is a nucleoside diphosphate. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulating the interleukin-6 (IL-6)/stat-3 pathway[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[References]

[1]. Angmo S, et al. Identification of Guanosine 5'-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. Sci Rep. 2017 Jan 5;7:40097.

Chemical & Physical Properties

[ Boiling Point ]:
961ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₃N₅Na₂O₁₁P₂

[ Molecular Weight ]:
487.16

[ Flash Point ]:
535ºC

[ Exact Mass ]:
486.988220

[ PSA ]:
277.85000

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3.0

Articles

The RasGrf family of mammalian guanine nucleotide exchange factors.

Biochim. Biophys. Acta 1815 , 170-188, (2011)

RasGrf1 and RasGrf2 are highly homologous mammalian guanine nucleotide exchange factors which are able to activate specific Ras or Rho GTPases. The RasGrf genes are preferentially expressed in the cen...

Models for the functions of Arf GAPs.

Semin. Cell. Dev. Biol. 22 , 3-9, (2011)

Arf GAPs (ADP-ribosylation factor GTPase-activating proteins) are essential components of Arf (ADP-ribosylation factor) signaling pathways. Arf GAPs stimulate the hydrolysis of GTP to GDP to transitio...

A novel GDP-dependent pyruvate kinase isozyme from Toxoplasma gondii localizes to both the apicoplast and the mitochondrion.

J. Biol. Chem. 283 , 14041-14052, (2008)

We previously reported a cytosolic pyruvate kinase (EC 2.7.1.40) from Toxoplasma gondii (TgPyKI) that differs from most eukaryotic pyruvate kinases in being regulated by glucose 6-phosphate rather tha...