Anagyrine hydrochloride

Names

[ CAS No. ]:
74195-83-8

[ Name ]:
Anagyrine hydrochloride

Biological Activity

[Description]:

Anagyrine ((-)-Anagyrine) hydrochloride is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine hydrochloride binds to muscarinic and nicotinic acetylcholine receptors with IC50 values of 132 and 2096 µM respectively. Anagyrine hydrochloride is a potent and effective desensitizer of nAChR, and Anagyrine hydrochloride can directly, without metabolism, desensitize nAChR[1][2][3].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR
Signaling Pathways >> GPCR/G Protein >> mAChR
Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR
Signaling Pathways >> Neuronal Signaling >> nAChR
Research Areas >> Neurological Disease

[In Vitro]

Anagyrine 在 SH-SY5Y 和 TE-671 两种细胞系中均充当部分激动剂， EC50 值分别为 4.2 和 231 μM。 Anagyrine 是 nAChR 的脱敏剂，在 SH-SY5Y 和 TE-671 细胞中的 DC50 值分别为 6.9 和 139 μM[3]。

[References]

[1]. Schmeller T, et al. Binding of quinolizidine alkaloids to nicotinic and muscarinic acetylcholine receptors. J Nat Prod. 1994 Sep;57(9):1316-9.  

[2]. Matsuda, K., et al. Nematicidal activities of (–)-N-methylcytisine and (–)-anagyrine from Sophora flavescens against pine wood nematodes. Agr. BioI. Chem. 53(8), 2287-2288 (1989).

[3]. Green BT, et al. Anagyrine desensitization of peripheral nicotinic acetylcholine receptors. A potential biomarker of quinolizidine alkaloid teratogenesis in cattle. Res Vet Sci. 2017 Dec;115:195-200.  

Chemical & Physical Properties

[ Molecular Formula ]:
C15H21ClN2O

[ Molecular Weight ]:
280.79

Related Compounds