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H-D-Phe-Phe-Arg-chloromethylketone trifluoroacetate salt

Names

[ CAS No. ]:
74392-49-7

[ Name ]:
H-D-Phe-Phe-Arg-chloromethylketone trifluoroacetate salt

[Synonym ]:
phenylalanyl-phenylalanyl-argininechloromethylketone
D-Phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-L-phenylalaninamide
H-D-PHE-PHE-ARG-CMK TFA
DPHE-PHE-ARG-CHLOROMETHYLKETONE
D-Phe-Phe-Arg Chloromethylketone Trifluoroacetate Salt
H-D-PHE-PHE-ARG-CHLOROMETHYLKETONE TRIFLUOROACETATE SALT
DPHE-PHE-ARG-CMK
PPACK II,TRIFLUOROACETATE SALT

Biological Activity

[Description]:

PPACK II is an irreversible and specific glandular and plasma kallikreins inhibitor[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease
Research Areas >> Cardiovascular Disease

[In Vitro]

PPACK II (0.62-50 μg/mL) 显着抑制 B 型钠尿肽 (BNP) 蛋白水解[2]。

[References]

[1]. Kentaro Takayama, et al. Identification of a degrading enzyme in human serum that hydrolyzes a C-terminal core sequence of neuromedin U. Biopolymers. 2016 Nov 4;106(4):440-5.  

[2]. Alexander Belenky, et al. The effect of class-specific protease inhibitors on the stabilization of B-type natriuretic peptide in human plasma. Clin Chim Acta. 2004 Feb;340(1-2):163-72.  

Chemical & Physical Properties

[ Density]:
1.308g/cm3

[ Molecular Formula ]:
C25H33ClN6O3

[ Molecular Weight ]:
501.02100

[ Exact Mass ]:
500.23000

[ PSA ]:
163.19000

[ LogP ]:
3.51290

[ Index of Refraction ]:
1.621

Related Compounds