Hippuryl-Phe-OH

Names

[ CAS No. ]:
744-59-2

[ Name ]:
Hippuryl-Phe-OH

[Synonym ]:
HIPPURYL-PHE-OH
BENZOYL-GLY-L-PHE
MFCD00037265
HIPPURYL-L-PHE
HIPP-L-PHE
Einecs 212-016-7
hippurylphenylalanine
L-Phenylalanine, N-benzoylglycyl-
hippuryl-L-phenylalanine
BENZOYL-GLY-PHE
HIPPURYL-PHE
BZ-GLY-PHE-OH
N-Benzoylglycyl-L-phenylalanine

Biological Activity

[Description]:

Hippuryl-L-phenylalanine is a substrate of carboxypeptidase. Carboxypeptidase is a protease enzyme that related with obesity, epilepsy and neurodegeneration. Hippuryl-L-phenylalanine can be used for the determination of carboxypeptidase activity[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Carboxypeptidase

[References]

[1]. Serafin WE, et al. Carboxypeptidase A in mouse mast cells. Identification, characterization, and use as a differentiation marker. J Immunol. 1987 Dec 1;139(11):3771-6.

[2]. Sapio MR, Fricker LD. Carboxypeptidases in disease: insights from peptidomic studies. Proteomics Clin Appl. 2014 Jun;8(5-6):327-37.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
673.3±55.0 °C at 760 mmHg

[ Melting Point ]:
140-144ºC

[ Molecular Formula ]:
C₁₈H₁₈N₂O₄

[ Molecular Weight ]:
326.346

[ Flash Point ]:
361.0±31.5 °C

[ Exact Mass ]:
326.126648

[ PSA ]:
95.50000

[ LogP ]:
2.18

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.600

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme.

Biochem. J. 462(3) , 441-52, (2014)

Ochratoxin, with ochratoxin A as the dominant form, is one of the five major mycotoxins most harmful to humans and animals. It is produced by Aspergillus and Penicillium species and occurs in a wide r...

Mast cell proteases.

Meth. Enzymol. 80 , 588, (1981)

Mechanisms for activation and inhibition of carboxypeptidase A catalyzed hydrolyses of peptides and esters.

Can. J. Biochem. 56 , 329, (1978)

3,3-Diphenylpropanoate (DPP) activates the carboxypeptidase A catalyzed hydrolysis of benzoylglycyl-L-phenylalanine (BzGly-L-Phe) (Ka = 2.1 x 10 (-3) M) and inhibits ester hydrolysis uncompetitively (...