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3-Hydroxy-4-methoxybenzaldehyde-d3

Names

[ CAS No. ]:
74495-73-1

[ Name ]:
3-Hydroxy-4-methoxybenzaldehyde-d3

[Synonym ]:
3-Hydroxy-4-methoxybenzaldehyde-d3
3-Hydroxyanisaldehyde-d3
5-Formyl-2-methoxyphenol-d3
2-Methoxy-5-formylphenol-d3
Isovanillin-d3
5-Formylguaiacol-d3

Biological Activity

[Description]:

Isovanillin-d3 is the deuterium labeled Isovanillin[1]. Isovanillin is an aldehyde oxidase inhibitor[2]. Antispasmodic activities[3]. Antidiarrheal activities[4].

[Related Catalog]:

Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Panoutsopoulos GI, et al. Enzymatic oxidation of vanillin, isovanillin and protocatechuic aldehyde with freshly prepared Guinea pig liver slices. Cell Physiol Biochem. 2005;15(1-4):89-98.  

[3]. Sadraei H, et al. Antispasmodic activity of isovanillin and isoacetovanillon in comparison with Pycnocycla spinosa Decne.exBoiss extract on rat ileum. Res Pharm Sci. 2014 May-Jun9(3):187-92.  

[4]. Sadraei H, et al. Antidiarrheal activities of isovanillin, iso-acetovanillon and Pycnocycla spinosa Decne ex.Boiss extract in mice. Res Pharm Sci. 2014 Mar-Apr9(2):83-9.  

Chemical & Physical Properties

[ Molecular Formula ]:
C8H8O3

[ Molecular Weight ]:
152.14700

[ Exact Mass ]:
152.04700

[ PSA ]:
46.53000

[ LogP ]:
1.21330

Related Compounds