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UBP 296

Names

[ CAS No. ]:
745055-86-1

[ Name ]:
UBP 296

[Synonym ]:
2-{[3-(2-Amino-2-carboxyethyl)-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl]methyl}benzoic acid
1(2H)-Pyrimidinepropanoic acid, α-amino-3-[(2-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo-
2-[[3-(2-amino-2-carboxyethyl)-2,6-dioxo-1-pyrimidinyl]methyl]benzoic acid
2-{[3-(2-Amino-2-carboxyethyl)-2,6-dioxo-3,6-dihydro-1(2H)-pyrimidinyl]methyl}benzoic acid

Biological Activity

[Description]:

UBP296 is a potent and selective antagonist of GLUK5-containing kainate receptor in the spinal cord. UBP296 reversibly blocks ATPA-induced depressions of synaptic transmission, and affects AMPA receptor-mediated synaptic transmission directly in rat hippocampal slices[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

IC50: 3.5 ± 1.5 μM (GLUK5), 4.0 ± 0.7 μM (GLUK5/GLUK6), 7.0 ± 5.1 μM (GLUK5/GLUK2)[1]


[References]

[1]. More JC, et al. Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology. 2004 Jul;47(1):46-64.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
603.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H15N3O6

[ Molecular Weight ]:
333.30

[ Flash Point ]:
318.5±34.3 °C

[ Exact Mass ]:
333.096100

[ LogP ]:
1.58

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.659

Related Compounds