Adenosine 5'-triphosphate magnesium salt

Names

[ Name ]:
Adenosine 5'-triphosphate magnesium salt

[Synonym ]:
Adenosine 5'-triphosphate magnesium salt
ATP magnesium salt
Adenosine 5 inverted exclamation marka-triphosphate magnesium salt
ATP-MG

Biological Activity

[Description]:

ATP (Adenosine 5'-triphosphate) dimagnesium is a central component of energy storage and metabolism in vivo. ATP dimagnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dimagnesium is an important endogenous signaling molecule in immunity and inflammation[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

Human Endogenous Metabolite

[In Vitro]

ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3]. ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner[4]. ATP promotes neutrophil chemotaxis in vitro[4].

[In Vivo]

ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4]. ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo[4]. Animal Model: Four-week-old Kunming mice (18-22 g)[4] Dosage: 50 mg/kg Administration: Intraperitoneal injection, before bacterial (E. coli) challenge Result: Protected mice from bacterial infection.

[References]

[1]. Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8.

[2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404.

[3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514.

[4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₄MgN₅O₁₃P₃

[ Molecular Weight ]:
529.47000

[ Exact Mass ]:
528.96500

[ PSA ]:
314.22000

[ Storage condition ]:
20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H371

[ Precautionary Statements ]:
P260

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
20/21/22-68/20/21/22

[ Safety Phrases ]:
36/37

[ RIDADR ]:
NONH for all modes of transport

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