3’-O-Acetyl-N2-iso-Butyroyl-2’-deoxy-guanosine

Names

[ Name ]:
3’-O-Acetyl-N2-iso-Butyroyl-2’-deoxy-guanosine

[Synonym ]:
Guanosine,2'-deoxy-N-(2-methyl-1-oxopropyl)-,3'-acetate

Biological Activity

[Description]:

3’-O-Acetyl-N2-iso-Butyroyl-2’-deoxy-guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₂₁N₅O₆

[ Molecular Weight ]:
379.37

[ Exact Mass ]:
379.14900

[ PSA ]:
152.18000

[ LogP ]:
0.98740