4-Amidinophenylmethanesulfonyl fluoride hydrochloride

Names

[ Name ]:
4-Amidinophenylmethanesulfonyl fluoride hydrochloride

[Synonym ]:
(4-Carbamimidoylphenyl)methanesulfonyl fluoride hydrochloride
(4-Carbamimidoylphenyl)methanesulfonyl fluoride hydrochloride (1:1)
Benzenemethanesulfonyl fluoride, 4-(aminoiminomethyl)-, hydrochloride (1:1)
(4-carbamimidoylphenyl)methanesulfonyl fluoride,hydrochloride
MFCD00036898

Biological Activity

[Description]:

p-APMSF is an irreversible inhibitor of serinase. p-APMSFhas substrate specificity for positively charged side chains of amino acids,lysine, or arginine. p-APMSF can be used to study the irreversible inhibitionof trypsin and thrombin [1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. LauraR, et al. (p-Amidinophenyl)methanesulfonyl fluoride, an irreversible inhibitorof serine proteases. Biochemistry. 1980 Oct 14;19(21):4859-64.

Chemical & Physical Properties

[ Boiling Point ]:
405.2ºC at 760 mmHg

[ Melting Point ]:
~205 °C (dec.)

[ Molecular Formula ]:
C₈H₁₀ClFN₂O₂S

[ Molecular Weight ]:
252.69

[ Flash Point ]:
198.8ºC

[ Exact Mass ]:
252.013550

[ PSA ]:
92.39000

[ LogP ]:
3.45280

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: 50 mM Stable when aliquoted at −20°C. Half-life = 6 minutes in pH 7.0 buffer systems.

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
20/21/22-36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2925290090

Customs

[ HS Code ]: 2925290090

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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