1-Nitrosopyrrolidine-2-carboxylic acid
Names
[ CAS No. ]:
7519-36-0
[ Name ]:
1-Nitrosopyrrolidine-2-carboxylic acid
[Synonym ]:
nitrosoproline
no-pro
1-nitroso-l-proline
L-nitrosoproline
1-Nitrosoproline
(S)-1-nitrosopyrrolidine-2-carboxylic acid
L-Proline,1-nitroso
(2S)-1-nitrosoproline
L-Proline,nitroso
N-NITROSO-PROLINE
NPRO
Chemical & Physical Properties
[ Density]:
1.572g/cm3
[ Boiling Point ]:
391.692ºC at 760 mmHg
[ Melting Point ]:
108-109ºC
[ Molecular Formula ]:
C5H8N2O3
[ Molecular Weight ]:
144.12900
[ Flash Point ]:
190.688ºC
[ Exact Mass ]:
144.05300
[ PSA ]:
69.97000
[ LogP ]:
0.15470
[ Index of Refraction ]:
1.629
[ Storage condition ]:
-20°C Freezer
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TW3680000
- CHEMICAL NAME :
- Proline, N-nitroso-, L-
- CAS REGISTRY NUMBER :
- 7519-36-0
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C5-H8-N2-O3
- MOLECULAR WEIGHT :
- 144.15
- WISWESSER LINE NOTATION :
- T5NTJ ANO BVQ -L
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 203 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 16,583,1973 ** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 770 mg/kg/8W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 16,583,1973 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 17,303,1978 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 17,303,1978 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987
Safety Information
[ Hazard Codes ]:
Xn