d(+)-histidinol dihydrochloride

Names

[ Name ]:
d(+)-histidinol dihydrochloride

[Synonym ]:
K295
histidinol dihydrochloride
(2R)-2-Amino-3-(1H-imidazol-4-yl)propan-1-ol dihydrochloride
D-Histidinol 2HCl
2-amino-3-(1H-imidazol-4-yl)propanol dihydrochloride
MFCD00012700
D-Histidinol dihydrochloride
(+-)-2-amino-3-(1(3)H-imidazol-4-yl)-propan-1-ol,dihydrochloride
(R)-2-Amino-3-(1H-imidazol-4-yl)propan-1-ol dihydrochloride
(2R)-2-Amino-3-(1H-imidazol-4-yl)-1-propanol dihydrochloride
1H-Imidazole-4-propanol, β-amino-, (βR)-, hydrochloride (1:2)

Chemical & Physical Properties

[ Melting Point ]:
193-195ºC(lit.)

[ Molecular Formula ]:
C₆H₁₃Cl₂N₃O

[ Molecular Weight ]:
214.093

[ Exact Mass ]:
213.043564

[ PSA ]:
74.93000

[ LogP ]:
1.57610

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933290090

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.

J. Biol. Chem. 286 , 403-9, (2011)

Topoisomerase II (Top2) activity involves an intermediate in which the topoisomerase is covalently bound to a DNA double-strand break via a 5'-phosphotyrosyl bond. Although these intermediates are nor...