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Cyclo(-Arg-Ala-Asp-D-Phe-Lys) trifluoroacetate salt

Names

[ CAS No. ]:
756500-23-9

[ Name ]:
Cyclo(-Arg-Ala-Asp-D-Phe-Lys) trifluoroacetate salt

[Synonym ]:
Cyclo(L-alanyl-L-α-aspartyl-D-phenylalanyl-L-lysyl-L-arginyl)
cyclo (Arg-Ala-Asp-d-Phe-Lys)
Cyclo(RADfK)

Biological Activity

[Description]:

Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis. Sequence: Cyclo(Ala-Asp-Phe-Lys-Arg).

[Related Catalog]:

Signaling Pathways >> Cytoskeleton >> Integrin
Research Areas >> Others
Peptides

[Target]

Integrin[1].


[In Vitro]

Cyclo(RADfK) is a negative control for the cyclo (-RGDfK-), the RGD peptide. RGD peptides are modulators of cell adhesion and are recognized by several members of the integrin family[1].

[References]

[1]. Srivatsan A, et al. Conjugation of cRGD peptide to chlorophyll a based photosensitizer (HPPH) alters its pharmacokinetics withenhanced tumor-imaging and photosensitizing (PDT) efficacy. Mol Pharm. 2011 Aug 1;8(4):1186-1197.


[Related Small Molecules]

Cilengitide | Cyclo(-Arg-Gly-Asp-D-Phe-Lys) trifluoroacetate salt | Arg-Gly-Asp-Ser | CWHM-12 | OSU-T315 | E 7820 | GLPG 0187 | Firategrast | ATN-161 trifluoroacetate salt | Cucurbitacin B | Eptifibatide acetate salt | iRGD peptide | Lifitegrast | Zaurategrast | Integrin Antagonist 1 (hydrochloride)

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C28H43N9O7

[ Molecular Weight ]:
617.69700

[ Exact Mass ]:
617.32900

[ PSA ]:
270.72000

[ LogP ]:
-2.75

[ Index of Refraction ]:
1.659

[ Storage condition ]:
-20°C

Related Compounds