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Mal-amido-PEG8-NHS ester

Names

[ CAS No. ]:
756525-93-6

[ Name ]:
Mal-amido-PEG8-NHS ester

[Synonym ]:
α-Maleimidopropionyl-ω-succinimidyl-8(ethylene glycol)
succinimidyl[(N-maleimidopropionamido)octaethyleneglycol]ester
Alpha-Maleimidopropionyl-ω-succinimidyl-8(ethylene glycol)
[3-[2-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-propionylamino]-ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-propionic acid-2,5-dioxo-pyrrolidin-1-yl ester
Maleimide-PEG8-NHS Ester

Biological Activity

[Description]:

Mal-amido-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H47N3O15

[ Molecular Weight ]:
689.70500

[ Exact Mass ]:
689.30100

[ PSA ]:
204.00000

[ Storage condition ]:
2-8°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds