Mal-amido-PEG4-NHS ester

Names

[ CAS No. ]:
756525-99-2

[ Name ]:
Mal-amido-PEG4-NHS ester

[Synonym ]:
monodisperse Mal-PEG4-NHS-ester
AmbotzPEG1575
Maleimide-PEG4-NHS Ester

Biological Activity

[Description]:

Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.36±0.1 g/cm3

[ Molecular Formula ]:
C₂₂H₃₁N₃O₁₁

[ Molecular Weight ]:
513.49500

[ Exact Mass ]:
513.19600

[ PSA ]:
170.57000

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport