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H2N-PEG8-CH2CH2COO<sup>t</sup>Bu

Names

[ CAS No. ]:
756526-06-4

[ Name ]:
H2N-PEG8-CH2CH2COO<sup>t</sup>Bu

[Synonym ]:
H2N-PEG8-CH2CH2COOtBu
H2N-PEG8- CH2CH2COOtBu

Biological Activity

[Description]:

Amino-PEG8-Boc is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Hans-Georg Lerchen, et al. Antibody drug conjugates (adcs) and antibody prodrug conjugates (apdcs) with enzymatically cleavable groups. WO2016207089A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H47NO10

[ Molecular Weight ]:
497.62000

[ Exact Mass ]:
497.32000

[ PSA ]:
126.16000

[ LogP ]:
1.51000

Safety Information

[ Hazard Codes ]:
Xn


Related Compounds