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2-Chloro-6-Methoxypurine-9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside

Names

[ CAS No. ]:
758705-70-3

[ Name ]:
2-Chloro-6-Methoxypurine-9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside

[Synonym ]:
MFCD25542515
9H-Purine, 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-6-methoxy-
2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-6-methoxy-9H-purine

Biological Activity

[Description]:

2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-6-methoxy-9H-purine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
547.9±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H12ClFN4O4

[ Molecular Weight ]:
318.69

[ Flash Point ]:
285.2±32.9 °C

[ Exact Mass ]:
318.053101

[ LogP ]:
1.21

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.736

Related Compounds