Z-Leu-Leu-Glu-βNA

Names

[ Name ]:
Z-Leu-Leu-Glu-βNA

[Synonym ]:
N-cbz-leu-leu-glu B-naphthylamide
Z-LEU-LEU-GLU-BETANA
Z-Leu-Leu-Glu-bNA

Biological Activity

[Description]:

Z-Leu-Leu-Glu-βNA (Z-Leu-Leu-Glu-β-naphthylamide) is a substrate for determination of the glutamylpeptidyl-peptide hydrolase activity of the 20S proteasome[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome

[References]

[1]. Reidlinger J, et al. Catalytic properties of 26 S and 20 S proteasomes and radiolabeling of MB1, LMP7, and C7 subunits associated with trypsin-like and chymotrypsin-like activities. J Biol Chem. 1997 Oct 3;272(40):24899-905.

Chemical & Physical Properties

[ Density]:
1.227g/cm3

[ Boiling Point ]:
896.1ºC at 760 mmHg

[ Molecular Formula ]:
C₃₅H₄₄N₄O₇

[ Molecular Weight ]:
632.74600

[ Flash Point ]:
495.8ºC

[ Exact Mass ]:
632.32100

[ PSA ]:
162.93000

[ LogP ]:
6.24560

[ Index of Refraction ]:
1.596

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H351

[ Precautionary Statements ]:
P281

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
40

[ Safety Phrases ]:
22-36

[ RIDADR ]:
NONH for all modes of transport

Articles

Activation of GluR6-containing kainate receptors induces ubiquitin-dependent Bcl-2 degradation via denitrosylation in the rat hippocampus after kainate treatment.

J. Thorac. Cardiovasc. Surg. 286 , 7669-80, (2011)

We previously showed that Bcl-2 (B-cell lymphoma 2) is down-regulated in a kainate (KA)-induced rat epileptic seizure model. The underlying mechanism had remained largely unknown, but we here report f...

Evidence that pituitary cation-sensitive neutral endopeptidase is a multicatalytic protease complex.

J. Neurochem. 40 , 842-849, (1983)

Pituitary cation-sensitive neutral endopeptidase splits peptide bonds on the carboxyl side of hydrophobic amino acids (chymotrypsin-like activity), basic amino acids (trypsin-like activity), and acidi...

Characterization of recombinant REGalpha, REGbeta, and REGgamma proteasome activators.

J. Biol. Chem. 272 , 25483, (1997)

Full-length cDNAs for three human proteasome activator subunits, called REGalpha, REGbeta, and REGgamma, have been expressed in Escherichia coli, and the purified recombinant proteins have been charac...