7-METHOXY-2-NITRONAPHTHO(2,1-b)FURAN
Names
[ CAS No. ]:
75965-74-1
[ Name ]:
7-METHOXY-2-NITRONAPHTHO(2,1-b)FURAN
[Synonym ]:
methoxy-7 nitro-2 naphto<2,1-b>furane
2-Nitro-7-methoxynaphtho(2,1-b)furan
7-methoxy-2-nitronaphtho[2,1-b]furan
5-nitrofuran
nitronaphthofuran (R-7000)
nitro-2 methoxy-7 naphto<2,1-b>furanne
R 7000
Chemical & Physical Properties
[ Density]:
1.379g/cm3
[ Boiling Point ]:
420ºC at 760 mmHg
[ Molecular Formula ]:
C13H9NO4
[ Molecular Weight ]:
243.21500
[ Flash Point ]:
207.8ºC
[ Exact Mass ]:
243.05300
[ PSA ]:
68.19000
[ LogP ]:
4.02600
[ Index of Refraction ]:
1.69
[ Storage condition ]:
2-8°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QL0840000
- CHEMICAL NAME :
- Naphtho(2,1-b)furan, 7-methoxy-2-nitro-
- CAS REGISTRY NUMBER :
- 75965-74-1
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 19
- MOLECULAR FORMULA :
- C13-H9-N-O4
- MOLECULAR WEIGHT :
- 243.23
- WISWESSER LINE NOTATION :
- T B566 EOJ DNW KO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 210 mg/kg/91W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 24 mg/kg/36W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 11967 ug/kg
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 20 mg/kg/10W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 360 mg/kg/12W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 mg/kg/5W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- Sperm Morphology
MUTATION DATA
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Bird - chicken Embryo
- DOSE/DURATION :
- 1 mg/L
- REFERENCE :
- AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 23,328,1983
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Res. Microbiol. 153(7) , 427-34, (2002)
Two nitrofurans present broad-spectrum antimicrobial properties and some of them are used in human and veterinary medicine. Most of these molecules are mutagens and some of them were reported as carci...
First characterization of the mutagenic specificity of 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000) in Salmonella typhimurium.Mutat. Res. 248(1) , 85-92, (1991)
In order to investigate the mutational events induced by the very potent genotoxic agent 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000), we evaluated its mutagenic potency in a battery of his- mutants o...
Influence of the uvr-dependent nucleotide excision repair on DNA adducts formation and mutagenic spectrum of a potent genotoxic agent: 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000).Mutat. Res. 358(1) , 113-22, (1996)
The influence of the uvr-dependent excision repair system on the lethal action, mutagenic specificity, SOS induction and DNA adducts formation of 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000), a potent...