Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate

Names

[ Name ]:
Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate

[Synonym ]:
MFCD00044575
ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate
EINECS 231-507-7

Biological Activity

[Description]:

Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate is an active compound, and can be used in the synthesis of 2-phenylthiomethyl-indole derivatives, 2-phenylthiomethyl-indole derivative is a 5-lipoxygenase (5-LO) inhibitor[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

Chemical & Physical Properties

[ Density]:
1.282 g/cm3

[ Boiling Point ]:
406.7ºC at 760 mmHg

[ Melting Point ]:
205-208ºC(lit.)

[ Molecular Formula ]:
C₁₂H₁₃NO₃

[ Molecular Weight ]:
219.23700

[ Flash Point ]:
199.7ºC

[ Exact Mass ]:
219.09000

[ PSA ]:
62.32000

[ LogP ]:
2.35860

[ Index of Refraction ]:
1.5270 (estimate)

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
F+

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3.0

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors.

J. Med. Chem. 51 , 4351, (2008)

1-Aroylindoline, 1-aroyl-1,2,3,4-tetrahydroquinoline, and 1-aroylindole derivatives were synthesized and evaluated for anticancer activity. The 4-amino and 4-hydroxy-1-aroylindoles 26 and 27 with IC 5...

Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors.

J. Med. Chem. 45 , 3094, (2002)

Previously, we reported on PD 102807 (41) as being the most selective synthetic M(4) muscarinic antagonist identified to date. Synthesized analogues of 41 showed no improvement in affinity and selecti...

5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity.

J. Med. Chem. 52 , 3855, (2009)

Obesity is a major risk factor in the development of conditions such as hypertension, hyperglycemia, dyslipidemia, coronary artery disease, and cancer. Several pieces of evidence across different spec...