Bromocresol Green

Names

[ CAS No. ]:
76-60-8

[ Name ]:
Bromocresol Green

[Synonym ]:
bromcresol green spray
m-Cresol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2,6-dibromo-, S,S-dioxide (8CI)
Bromocresol Green p.a.
MYCOBACTERIUM BOVIS
BCG
Bromcresol Green
BROMOCRESOL GREEN,ACS
2,2'-dimethyl-3,3',5,5'-tetrabromophenolsulfophthalein
EINECS 200-972-8
3',3'',5',5''-Tetrabromo-m-cresolsulfonephthalein
vertdebromocresol
2,2'-dimethyl-3,3',5,5'-tetrabromophenolsulphonephthalein
3',3",5',5"-tetrabromo-m-cresolsulfonapthalein
Phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo-3-methyl-
a,a-Bis(3,5-dibromo-4-hydroxy-o-tolyl)-a-hydroxytoluenesulfonic Acid g-Sultone
3′,3′′,5′,5′′-Tetrabromo-m-cresolsulfonephthalein
BCG,Mycobacterium bovis
4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bis[2,6-dibromo-3-methylphenol] S,S-Dioxide
BBOT
3,3',5,5'-Tetrabromo-m-cresolsulfonphthalein
BROMOCRESOL BLUE
MFCD00005874
4,4'-(1,1-Dioxido-3H-2,1-benzoxathiole-3,3-diyl)bis(2,6-dibromo-3-methylphenol)
Bromocresol Green

Biological Activity

[Description]:

Bromocresol green is a pH-sensitive triphenylmethane dye commonly used for the determination of protein and albumin in serum. Bromocresol green is a bio-based dye with a yellow-green to blue-green color. Bromocresol green turns yellow (λmax=435 nm, protonated form) when placed in acidic solution (e.g. pH=4.15), and turns blue in basic solution (λmax=615 nm, deprotonated form). Bromocresol green is widely used as a pH indicator in the field of biochemical analysis. In addition, Bromocresol green is also used to detect the concentration of molecules such as creatinine, and to judge the viability of cells[1][2][3][4].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Delanghe S, et al. Binding of bromocresol green and bromocresol purple to albumin in hemodialysis patients. Clin Chem Lab Med. 2018 Feb 23;56(3):436-440.

[2]. Jurmanović S, et al. Organically modified silicate thin films doped with colourimetric pH indicators methyl red and bromocresol green as pH responsive sol–gel hybrid materials[J]. Thin Solid Films, 2010, 518(8): 2234-2240.

[3]. Chaiyo S, et al. A novel paper-based colorimetry device for the determination of the albumin to creatinine ratio. Analyst. 2018 Nov 5;143(22):5453-5460.

[4]. Hou H, et al. Single-cell pH imaging and detection for pH profiling and label-free rapid identification of cancer-cells. Sci Rep. 2017 May 11;7(1):1759.

Chemical & Physical Properties

[ Density]:
2.1±0.1 g/cm3

[ Boiling Point ]:
626.0±55.0 °C at 760 mmHg

[ Melting Point ]:
225 °C

[ Molecular Formula ]:
C₂₁H₁₄Br₄O₅S

[ Molecular Weight ]:
698.01

[ Flash Point ]:
332.4±31.5 °C

[ Exact Mass ]:
693.729492

[ PSA ]:
92.21000

[ LogP ]:
7.80

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.716

[ Storage condition ]:
Store at RT.

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
slightly soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SJ7456000

CHEMICAL NAME :: Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2,6-dibromo-3 -methyl-, S,S-dioxide

CAS REGISTRY NUMBER :: 76-60-8

BEILSTEIN REFERENCE NO. :: 0372527

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C21-H14-Br4-O5-S

MOLECULAR WEIGHT :: 698.05

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H319-H336

[ Precautionary Statements ]:
P210-P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S7-S16-S24/25-S26-S37/39

[ RIDADR ]:
UN 1219 3/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
SJ7456000

[ Hazard Class ]:
3.0

[ HS Code ]:
2934991000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934991000

[ Summary ]:
2934991000. sultones and sultams. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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