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FA-Ala-Arg-OH

Names

[ CAS No. ]:
76079-06-6

[ Name ]:
FA-Ala-Arg-OH

[Synonym ]:
L-Arginine,N(2)-(N-(3-(2-furanyl)-1-oxo-2-propenyl)-L-alanyl)
FA-Ala-arg
Furylacryloylalanylarginine
(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[(E)-3-furan-2-ylprop-2-enoyl]amino]propanoyl]amino]pentanoic acid
Furylacryloyl-ala-arg

Biological Activity

[Description]:

FA-Ala-Arg is a dipeptide with furylacryloyl group. FA-Ala-Arg breaks down to produce arginine. While cell-surface Carboxypeptidase-D (CPD) also increases intracellular Arg, which is converted to nitric oxide (NO). FA-Ala-Arg enhances NO production in MCF-7 cells. FA-Ala-Arg also increases the cell survival of prolactin (PRL)-treated cells, PRL regulates CPD mRNA levels in cells[1].

[Related Catalog]:

Research Areas >> Endocrinology

[References]

[1]. Abdelmagid SA, et al. Prolactin and estrogen up-regulate carboxypeptidase-d to promote nitric oxide production and survival of mcf-7 breast cancer cells. Endocrinology. 2008 Oct;149(10):4821-8.  

Chemical & Physical Properties

[ Density]:
1.38g/cm3

[ Molecular Formula ]:
C16H23N5O5

[ Molecular Weight ]:
365.38

[ Exact Mass ]:
365.17000

[ PSA ]:
177.52000

[ LogP ]:
2.50170

[ Index of Refraction ]:
1.608

[ Storage condition ]:
-15°C

Related Compounds